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慢性阻塞性肺疾病作为一种发病率及致死率较高的常见慢性疾病，其早期预防、诊治可有效降低其发病率，改善预后，减轻患者家庭经济负担。随着分子生物学研究的深入，lncRNA成为近几年研究热点，其参与疾病的发生、发展及转归，为疾病研究提供新的方向。本文就lncRNA生物学特性及其与慢性阻塞性肺疾病的诱因、病理变化及治疗药物间联系的研究进展作一综述。
Abstract：Chronic obstructive pulmonary disease is a common chronic disease with high morbidity and mortality. Early prevention,diagnosis and treatment of chronic obstructive pulmonary disease can effectively reduce its morbidity,improve prognosis,and reduce the economic burden of patients' families. With the deepening of molecular biology research,lncRNAs have become a research hotspot in recent years. They are involved in the occurrence,development and prognosis of diseases,providing new directions for disease research. This article reviews the research progress on the biological characteristics of lncRNAs and their association with the causes,pathological changes and therapeutic drugs of chronic obstructive pulmonary disease.
1 Kazimierczyk M,Kasprowicz MK,Kasprzyk ME,et al.Human long noncoding RNA interactome:Detection,characterization and function[J]. Int J Mol Sci,2020,21(3):1027.
2 Rion N,Ruegg MA. LncRNA-encoded peptides:More than translational noise?[J]. Cell Res,2017,27(5):604-605.
3 Brown CJ,Ballabio A,Rupert JL,et al. A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome[J].Nature,1991,349(6304):38-44.
4 Rinn JL,Kertesz M,Wang JK,et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs[J]. Cell,2007,129(7):1311-1323.
5 Statello L,Guo CJ,Chen LL,et al. Gene regulation by long non-coding RNAs and its biological functions[J].Nat Rev Mol Cell Biol,2021,22(2):96-118.
6 Zuckerman B,Ron M,Mikl M,et al. Gene architecture and sequence composition underpin selective dependency of nuclear export of long RNAs on NXF1 and the TREX complex[J]. Mol Cell,2020,79(2):251-267 e6.
7 潘剑锋，张燕军，李金泉.不同亚细胞结构中的长非编码RNA[J].中国生物化学与分子生物学报，2022,38(2):165-174.
8 Schmitz SU,Grote P,Herrmann BG. Mechanisms of long noncoding RNA function in development and disease[J]. Cell Mol Life Sci,2016,73(13):2491-2509.
9 Chodroff RA,Goodstadt L,Sirey TM,et al. Long noncoding RNA genes:Conservation of sequence and brain expression among diverse amniotes[J]. Genome Biol,2010,11(7):R72.
10 Zhu Y,Mao D,Gao W,et al. Analysis of lncRNA expression in patients with eosinophilic and neutrophilic asthma focusing on LNC_000127[J]. Front Genet,2019,10:141.
11 Ye S,Zhu S,Feng L. LncRNA ANRIL/miR-125a axis exhibits potential as a biomarker for disease exacerbation,severity,and inflammation in bronchial asthma[J].J Clin Lab Anal,2020,34(3):e23092.
12 Shen Y,Yang G,Zhuo S,et al. lncRNA FTX promotes asthma progression by sponging miR-590-5p and upregulating JAK2[J]. Am J Transl Res,2021,13(8):8833-8846.
13 Liu JH,Li C,Zhang CH,et al. LncRNA-CASC7 enhances corticosteroid sensitivity via inhibiting the PI3K/AKT signaling pathway by targeting miR-21 in severe asthma[J]. Pulmonology,2020,26(1):18-26.
14 Feng Y, Yang C, Yan W. Expression of lncRNA MEG3 in asthma with different phenotypes and its relationship with course of disease[J]. Exp Ther Med,2020,19(3):2211-2217.
15 Lin S,Zhang R,Xu L,et al. LncRNA Hoxaas3 promotes lung fibroblast activation and fibrosis by targeting miR-450b-5p to regulate Runx1[J]. Cell Death Dis,2020,11(8):706.
16 Hadjicharalambous MR, Roux BT, Feghali-Bostwick CA,et al. Long non-coding RNAs are central regulators of the IL-1beta-induced inflammatory response in normal and idiopathic pulmonary lung fibroblasts[J]. Front Immunol,2018,9:2906.
17 Ku GW,Kang Y,Yu SL,et al. LncRNA LINC00240suppresses invasion and migration in non-small cell lung cancer by sponging miR-7-5p[J]. BMC Cancer,2021,21(1):44.
18 Zhen Q,Gao LN,Wang RF,et al. LncRNA DANCR promotes lung cancer by sequestering miR-216a[J]. Cancer Control,2018,25(1):1073274818769849.
19 Ren MM,Xu S,Wei YB,et al. Roles of HOTAIR in lung cancer susceptibility and prognosis[J]. Mol Genet Genomic Med,2020,8(7):e1299.
20 Bo Y,Chang LY,Guo C,et al. Reduced ambient PM2.5, better lung function, and decreased risk of chronic obstructive pulmonary disease[J]. Environ Int,2021,156:106706.
21 Li X,Zheng M,Pu J,et al. Identification of abnormally expressed lncRNAs induced by PM2.5 in human bronchial epithelial cells[J]. Biosci Rep, 2018, 38(5):BSR20171577.
22 Zhao J,Pu J,Hao B,et al. LncRNA RP11-86H7.1 promotes airway inflammation induced by TRAPM2.5 by acting as a ceRNA of miRNA-9-5p to regulate NFKB1in HBECS[J]. Sci Rep,2020,10(1):11587.
23 Tran I,Ji C,Ni I,et al. Role of cigarette smoke-induced aggresome formation in chronic obstructive pulmonary disease-emphysema pathogenesis[J]. Am J Respir Cell Mol Biol,2015,53(2):159-173.
24 Zhang H,Sun D,Li D,et al. Long non-coding RNA expression patterns in lung tissues of chronic cigarette smoke induced COPD mouse model[J]. Sci Rep,2018,8(1):7609.
25 Shen Q,Zheng J,Wang X,et al. LncRNA SNHG5 regulates cell apoptosis and inflammation by miR-132/PTEN axis in COPD[J]. Biomed Pharmacother,2020,126:110016.
26 Gu W,Yuan Y,Wang L,et al. Long non-coding RNA TUG1 promotes airway remodelling by suppressing the miR-145-5p/DUSP6 axis in cigarette smoke-induced COPD[J]. J Cell Mol Med,2019,23(11):7200-7209.
27 Ding Y,Li Q,Feng Q,et al. CYP2B6 genetic polymorphisms influence chronic obstructive pulmonary disease susceptibility in the Hainan population[J]. Int J Chron Obstruct Pulmon Dis,2019,14:2103-2115.
28 Zhou X, Zhang Y, Zhang Y, et al. LINC01414/LINC00824 genetic polymorphisms in association with the susceptibility of chronic obstructive pulmonary disease[J]. BMC Pulm Med,2021,21(1):213.
29 Bi H,Zhou J,Wu D,et al. Microarray analysis of long non-coding RNAs in COPD lung tissue[J]. Inflamm Res,2015,64(2):119-126.
30 Hogg JC,Timens W. The pathology of chronic obstructive pulmonary disease[J]. Annu Rev Pathol,2009,4:435-459.
31 Vignola AM,Mirabella F,Costanzo G,et al. Airway remodeling in asthma[J]. Chest,2003,123(3 Suppl):417 S-422S.
32 中华医学会呼吸病学分会慢性阻塞性肺疾病学组，中国医师协会呼吸医师分会慢性阻塞性肺疾病工作委员会.慢性阻塞性肺疾病诊治指南（2021年修订版）[J].中华结核和呼吸杂志，2021,44(3):170-205.
33 Zhao K,Tu C,Liang K,et al. Long noncoding RNA MCM3AP antisense RNA 1 is downregulated in chronic obstructive pulmonary disease and regulates human bronchial smooth muscle cell proliferation[J]. J Int Med Res,2020,48(9):300060520935215.
34 Zheng M,Hong W,Gao M,et al. Long noncoding RNA COPDA1 Promotes airway smooth muscle cell proliferation in chronic obstructive pulmonary disease[J]. Am J Respir Cell Mol Biol,2019,61(5):584-596.
35 Fricker M,Gibson PG. Macrophage dysfunction in the pathogenesis and treatment of asthma[J]. Eur Respir J,2017,50(3):1700196.
36 Li N,Liu Y,Cai J. LncRNA MIR155HG regulates M1/M2 macrophage polarization in chronic obstructive pulmonary disease[J]. Biomed Pharmacother, 2019,117:109015.
37 Qi X,Chen H,Fu B,et al. LncRNAs NR-026690 and ENST00000447867 are upregulated in CD4(+)T cells in patients with acute exacerbation of COPD[J]. Int J Chron Obstruct Pulmon Dis,2019,14:699-711.
38 Zhou AY,Zhao YY,Zhou ZJ,et al. Microarray analysis of long non-coding RNAs in lung tissues of patients with COPD and HOXA-AS2 promotes HPMECs proliferation via Notch1[J]. Int J Chron Obstruct Pulmon Dis,2020,15:2449-2460.
39 Bi H,Wang G,Li Z,et al. Long noncoding RNA(lncRNA)maternally expressed gene 3(MEG3)participates in chronic obstructive pulmonary disease through regulating human pulmonary microvascular endothelial cell apoptosis[J]. Med Sci Monit,2020,26:e920793.
40 Chen X,Mao M,Shen Y,et al. lncRNA TUG1 regulates human pulmonary microvascular endothelial cell apoptosis via sponging of the miR-9a-5p/BCL2L11 axis in chronic obstructive pulmonary disease[J]. Exp Ther Med,2021,22(2):906.
41 Zhang Y,Jia S,Gao T,et al. Dexmedetomidine mitigate acute lung injury by inhibiting IL-17-induced inflammatory reaction[J]. Immunobiology,2018,223(1):32-37.
42 Du XH,Li SS,Xiong GS,et al. Therapeutic efficacy of dexmedetomidine on chronic obstructive pulmonary disease via downregulating lncRNA PACER[J]. Eur Rev Med Pharmacol Sci,2020,24(24):12963-12970.
43 Xia H,Xue J,Xu H,et al. Andrographolide antagonizes the cigarette smoke-induced epithelial-mesenchymal transition and pulmonary dysfunction through anti-inflammatory inhibiting HOTAIR[J]. Toxicology,2019,422:84-94.
44 Zhou M,Wang H,Zeng X,et al. Mortality,morbidity,and risk factors in China and its provinces,1990-2017:Asystematic analysis for the Global Burden of Disease Study 2017[J]. Lancet,2019,394(10204):1145-1158.
基本信息:
DOI：10.13210/j.cnki.jhmu.20220412.001
中图分类号:R563.9
引用信息:
[1]何蝉伊,丁毅鹏.lncRNA与COPD发病机制的相关研究进展[J].海南医学院学报,2022,28(17):1350-1355+1360.DOI:10.13210/j.cnki.jhmu.20220412.001.
基金信息:
国家自然科学基金资助项目（81860015）~~
2022-04-13
2022-04-13
2022-04-13