海南医科大学学报

目的:采取数据挖掘技术探讨巴元明教授治疗慢性肾炎(CGN)的用药规律,为临床及科研于慢性肾炎的中医药治疗方面提供一定的参考依据。方法:收集、整理、筛选巴元明教授2018～2019年于湖北省中医院门诊部诊疗的慢性肾炎患者病例,于古今医案云平台(V2.2.1)建立数据库并采用频次统计、关联规则、层次聚类等分析方法对使用药物进行研究分析。结果:纳入处方1 630例,涉及中药212味。高频药物为茯苓、黄芪、党参、山药、穿山龙、山茱萸、分心木等;药性以温、寒、平性为主;五味喜用偏甘淡、辛苦之品;归经多见于肾、肺、脾经;功效则以宁心安神、健脾和胃、利水消肿等多见。获得黄芪-茯苓等多组核心中药组合。结论:巴元明教授治疗CGN重视统筹兼顾、攻补兼施,重视顾护三焦正气的同时清热利湿、化瘀、固涩,擅用甘平和缓之品。

Objective:To explore the medication rule of Professor Ba Yuanming in the treatment of chronic glonerulonephritis(CGN)by data mining technology,so as to provide certain reference for clinical and scientific research in the treatment of Chronic glonerulonephritis with traditional Chinese medicine.Methods:This study collected,sorted out and screened the cases of chronic nephritis diagnosed and treated by Professor Ba Yuanming in the Outpatient department of Hubei Hospital of Traditional Chinese Medicine from 2018 to 2019,established the database on the cloud platform of ancient and modern medical cases(v2.2.1),and used frequency statistics,association rules,hierarchical clustering and other analysis methods to study and analyze the drugs used.Results:Totally 1 630 cases were included in the prescription,involving 212 traditional Chinese medicines. The high-frequency drugs were Poria cocos,Astragalus,dangshen,yam,Chuanshanlong,Cornus,distracted wood,etc.;the nature of drugs were mainly warm,cold and calm;the five tastes preferred sweet,spicy and bitter,etc;the meridian tropism was mostly found in the kidney,lung and spleen channels;the effects were tranquilizing the heart and mind,strengthening the spleen and stomach,promoting water and swelling. The core Chinese medicine combinations of Astragalus and Poria were obtained.Conclusion:Professor Ba Yuan-ming highlights the comprehensive consideration and supplement in the treatment of CGN,pays attention to the care of the healthy qi of Sanjiao,at the same time clears away heat and dampness,removes blood stasis and firmness,and is good at using the sweet and gentle products.