海南医科大学学报

目的:探讨美沙拉嗪治疗老年溃疡性结肠炎(UC)的临床疗效及不良反应。方法:选择老年UC患者80例,随机分为两组:试验组41例,予口服美沙拉嗪;对照组39例,予口服柳氮磺胺吡啶,比较两组治疗前、后临床症状、结肠镜检查、血沉(ESR)、C反应蛋白(CRP)水平及肝肾功能的变化。结果:试验组总有效率(85.37%)明显高于对照组(66.67%),差异有统计学意义(P<0.05);治疗后,试验组ESR、CRP水平均明显低于对照组,差异有统计学意义(P<0.01);试验组不良反应发生率较对照组低,治疗前、后两组肝肾功能未见明显异常。结论:美沙拉嗪治疗老年UC较柳氮磺胺吡啶临床疗效显著,不良反应少,安全性高,适合推广运用。

Objective: To explore the clinical effect and adverse reaction of mesalazine on elderly patients with ulcerative colitis(UC).Methods: A total of 80 elderly patients with UC were divided into experimental group(oral mesalazine) and control group(oral salicylazosulfapyridine).The clinical symptoms,colonoscope,levels of ESR,CRP and hepatic and renal function were observed.Results: The total effective rate in experimental group(85.37%) was significantly higher than that in control group(66.67%)(P<0.05),and the level of ESR and CRP in experiment group were significantly lower than that in control group(P<0.05).The rate of adverse reaction of experimental group was lower than that of control group.There was no obvious abnormality in hepatic and renal function of the two groups.Conclusion: The clinical effect of mesalazine on elderly patients is better than salicylazosulfapyridine,with fewer adverse reactions and high security,and it is worthy clinical application.