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缺血性脑卒中（ischemic stroke,IS）是导致高致残率和死亡率的重大神经系统疾病，现有治疗手段如血管内机械取栓和静脉溶栓面临疗效局限和时间窗狭窄等挑战。近年来，中医药因其天然多靶点的特性，逐渐成为IS治疗的研究热点。脑源性神经营养因子（BDNF）/原肌球蛋白激酶受体B(Trk B)信号通路在神经发生、突触可塑性、神经保护及血管新生等方面发挥关键作用，成为调控神经功能恢复的关键路径。大量研究表明，BDNF/Trk B信号通路在IS的发生与发展中起着至关重要的作用，其激活能够促进神经修复、减少细胞凋亡、改善突触可塑性及促进脑血管新生。中药通过调节BDNF/Trk B信号通路发挥神经保护作用，已成为探索IS治疗的新兴方向。本文通过综述BDNF/Trk B信号通路在IS中的作用机制，分析近年来中药调控此通路治疗IS的研究进展，并探讨相关中药复方及其活性成分在改善IS症状、促进神经恢复中的潜力。通过系统分析，本文为未来中药在IS治疗中的应用及研究提供一定的理论依据与参考，为其临床治疗提供新的策略与思路。
Abstract：Ischemic stroke(IS) is a major neurological disorder characterized by high disability and mortality rates. Current treatments, such as endovascular mechanical thrombectomy and intravenous thrombolysis, face challenges including limited efficacy and narrow therapeutic time windows. In recent years, traditional Chinese medicine(TCM) has emerged as a research hotspot for IS treatment due to its natural multi-target properties. The brain-derived neurotrophic factor(BDNF)/tropomyosin receptor kinase B(Trk B) signaling pathway plays a pivotal role in neurogenesis, synaptic plasticity, neuroprotection, and angiogenesis, making it a key pathway for regulating neurological recovery. Extensive studies indicate that the BDNF/Trk B pathway is critically involved in the pathogenesis and progression of IS. Its activation promotes neural repair, reduces apoptosis, enhances synaptic plasticity, and stimulates cerebral angiogenesis. TCM, by modulating the BDNF/Trk B pathway to exert neuroprotective effects, has become a promising direction for exploring novel IS therapies. This article reviews the mechanisms of the BDNF/Trk B pathway in IS, analyzes recent advances in TCM-mediated regulation of this pathway for IS treatment, and discusses the potential of TCM formulations and their active components in alleviating IS symptoms and promoting neurological recovery. Through systematic analysis, this review provides theoretical foundations and references for future applications of TCM in IS treatment, as well as new strategies and insights for clinical practice.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20250520.003
中图分类号:R277.7
引用信息:
[1]包璇,金华,杜婕,等.中药调控BDNF/Trk B信号通路治疗缺血性脑卒中的研究进展[J].海南医科大学学报,2025,31(15):1189-1200.DOI:10.13210/j.cnki.jhmu.20250520.003.
基金信息:
国家自然科学基金地区基金资助项目(82160886); 甘肃省省级重点人才项目(2023RCXM28); 甘肃省省级科技计划项目(23JRRA1524)~~
2025-05-21
2025-05-21
2025-05-21