海南医科大学学报

目的:探讨急性有机磷农药中毒(AOPP)患者血清C反应蛋白(CRP)的改变及临床价值。方法:采用免疫比浊法测定117例AOPP患者和120例健康体检者血清CPR水平,并做相关性分析。结果:AOPP组入院时、入院第13、7、d的血清CRP水平均显著高于对照组,差异有统计学意义(P<0.05)。血清CPR水平随着中毒程度加重而升高,且与中毒程度分级呈正相关(r=0.6136,P<0.01)。结论:AOPP患者血清CRP浓度的变化与患者中毒程度和炎症反应有关,动态观察AOPP患者血清CRP的变化,对了解病情、指导治疗和判断预后有重要的价值。

Objective: To study the variation and clinical significance of serum C-reactive protein(CRP) in patients with acute organophosphorus pesticide poisoning(AOPP).Methods: A total of 117 patients with AOPP and 120 healthy cases were selected.The serum CRP level was detected using immunoturbidimetry methods.Results: The serum CRP level of the AOPP group were significantly higher than the control group as admission,and on 1 d,3 d and 7 d after admission(P<0.05).The serum CRP level increased as elevating degree of poisoning,and the degree of poisoning was positively correlated with CRP level(r=0.6136,P<0.01).Conclusions: The changes of serum CRP level in the AOPP are related with degree of poisoning and inflammation.Dynamic monitoring of serum CRP is important for treatment and prognosis.